CHENG, Richard P.
Professor
Room B678, Chemistry Building
Fax: +886-2-3366-8671
Research Interest
- Synthesis, conformational properties, and applications of non-natural amino acids.
- Fluorine-containing amino acids, charged amino acids, nucleic acid recognition, cell penetration, drug delivery.
Career and Service Experiences
- B.S., 1992, Department of Chemistry, National Taiwan University.
- Ph.D., 1998, Division of Chemistry and Chemical Engineering, California Institute of Technology.
- Postdoctoral Fellow, 1998-2002, University of Pennsylvania.
- Assistant Professor, 2002-2008, Department of Chemistry, The State University of New York at Buffalo.
- Associate Professor, 2008-2015, Department of Chemistry, National Taiwan University.
- Professor, 2015-present, Department of Chemistry, National Taiwan University.
Honors and Awards
- James D. Watson Young Investigator Award, 2003-2004; New York State Office of Science, Technology & Academic Research.
- Recruiting Outstanding Young Scholar Award, 2008-2013; Foundation for the Advancement of Outstanding Scholarship.
- Asian Core Program Lectureship Award, 2010; New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia.
- Outstanding Young Chemist Award, 2010; The Chemical Society Located in Taipei.
- Excellence in Teaching Award, 2010, 2012-2014; National Taiwan University.
Selected Publications
- Chang, J.-Y.; Pan, Y.-J.; Huang, P.-Y.; Sun, Y.-T.; Yu, C.-H.; Ning, Z.-J.; Huang, S.-L.; Huang, S.-J.; Cheng, R. P.* “Effect of charged amino acid side chain length on diagonal cross-strand interactions between carboxylate- and ammonium-containing residues in a beta-hairpin” Molecules 2022, 27, in press.
- Chang, J.-Y.; Li, N.-Z.; Wang, W.-M.; Liu, C.-T.; Yu, C.-H.; Chen, Y.-C.; Lu, D.; Lin, P.-H.; Huang, C.-H.; Kono, O.; Yang, T.-Y.; Sun, Y.-T.; Huang, P.-Y.; Pan, Y.-J.; Chen, T.-H.; Liu, M.-C.; Huang, S.-L.; Huang, S.-J.; Cheng, R. P.* “Longer charged amino acids favor beta-strand formation in hairpin peptides” J. Pept. Sci. 2021, 27, e3333.
- Huang, C.-H.; Wong, T. W.; Yu, C.-H.; Chang, J.-Y.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Swapping the positions in a cross-strand lateral ion-pairing interaction between ammonium- and carboxylate-containing residues in a beta-hairpin” Molecules 2021, 26, 1346.
- Wang, W.-M.; Yu, C.-H.; Chang, J.-Y.; Chen, T.-H.; Chen, Y.-C.; Sun, Y.-T.; Wang, S.-H.; Jao, S.-C.; Cheng, R. P.* “Insertion of Pro-Hyp-Gly provides 2 kcal/mol stability but attenuates the specific assembly of ABC heterotrimeric collagen triple helices” Org. Biomol. Chem. 2021, 19, 1860–1866.
- Wu, P.-Y.; Chen, C.-Y.; Li, J.-H.; Lin, J.-K.; Chen, T.-H.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of arginine deimination and citrulline side chain length on secondary structure formation” ChemBioChem 2019, 20, 2118–2124.
- Liu, M.-C.; Chen, C.-Y.; Chiang, C.-H.; Wang, W.-M.; Cheng, R. P.* “Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides” Bioorg. Med. Chem. 2016, 24, 5047–5051.
- Wu, C.-H.; Chen, Y.-P.; Liu, S.-L.; Chien, F.-C.; Mou, C.-Y.; Cheng, R. P.* “Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues” Org. Biomol. Chem. 2015, 13, 11096–11104.
- Kuo, H.-T.; Liu, S.-L.; Chiu, W.-C.; Fang, C.-J.; Chang, H.-C.; Wang, W.-R.; Yang, P.-A.; Li, J.-H.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate- and guanidinium-containing residues in a beta-hairpin” Amino Acids 2015, 47, 885–898.
- Li, J.-H.; Chiu, W.-C.; Yao, Y.-C.; Cheng, R. P.* “Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides” Biorg. Med. Chem. 2015, 23, 2281–2286.
- Kuo, H.-T.; Yang, P.-A.; Wang, W.-R.; Hsu, H.-C.; Wu, C.-H.; Ting, Y.-T.; Weng, M.-H.; Kuo, L.-H.; Cheng, R. P.* “Effect of side chain length on intrahelical interactions between carboxylate- and guanidinium-containing amino acids” Amino Acids 2014, 46, 1867–1883.
- Wu, C.-H.; Weng, M.-H.; Chang, H.-C.; Li, J.-H.; Cheng, R. P.* “Effect of each guanidinium group on the RNA recognition and cellular uptake of Tat-derived peptides” Bioorg. Med. Chem. 2014, 22, 3016–3020.
- Kuo, H.-T.; Fang, C.-J.; Tsai, H.-Y.; Yang, M.-F.; Chang, H.-C.; Liu, S.-L.; Kuo, L.-H.; Wang, W.-R.; Yang, P.-A.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate-containing residues and lysine analogs in a beta-hairpin” Biochemistry 2013, 52, 9212–9222.
- Wu, C.-H.; Chen, Y.-P.; Wu, S.-H.; Hung, Y.; Mou, C.-Y.*; Cheng, R. P.* “Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain” ACS Appl. Mat. Inter. 2013, 5, 12244–12248
- Kuo, L.-H.; Li, J.-H.; Kuo, H.-T.; Hung, C.-Y.; Tsai, H.-Y.; Chiu, W.-C.; Wu, C.-H.; Wang, W.-R.; Yang, P.-A.; Yao, Y.-C.; Wong, T. W.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length at non-hydrogen bonded strand positions on beta-hairpin stability” Biochemistry 2013, 52, 7785–7797.
- Wu, C.-H.; Chen, Y.-P.; Mou, C.-Y.; Cheng, R. P.* “Altering the Tat-derived peptide bioactivity landscape by changing the arginine side chain length” Amino Acids 2013, 44, 473–480.
- Cheng, R. P.*; Wang, W.-R.; Girinath, P.; Yang, P.-A.; Ahmad, R.; Li, J.-H.; Hart, P.; Kokona, B.; Fairman, R.; Kilpatrick, C.; Argiros, A. “Effect of glutamate side chain length on intrahelical glutamate-lysine ion pairing interactions” Biochemistry 2012, 51, 7157–7172.
- Cheng, R. P.*; Weng, Y.-J.; Wang, W.-R.; Koyack, M. J.; Suzuki, Y.; Wu, C.-H.; Yang, P.-A.; Hsu, H.-C.; Kuo, H.-T.; Girinath, P.; Fang, C.-J “Helix formation and capping energetics of arginine analogs with varying side chain length” Amino Acids 2012, 43, 195–206.
- Cheng, R. P.*; Girinath, P.; Suzuki, Y.; Kuo, H.-T.; Hsu, H.-C.; Wang, W.-R.; Yang, P.-A. Gullickson, D.; Wu, C.-H.; Koyack, M. J.; Chiu, H.-P.; Weng, Y.-J.; Hart, P.; Kokona, B.; Fairman, R.; Lin, T.-E.; Barrett, O. “Positional effects on helical Ala-based peptides” Biochemistry 2010, 49, 9372–9384.
- Chiu, H.-P.; Kokona, B.; Fairman, R.; Cheng, R. P.* “Effect of highly fluorinated amino acids on protein stability at a solvent-exposed position on an internal strand of protein G B1 domain” J. Am. Chem. Soc. 2009, 131, 13192–13193.
Update: 2022-03-23