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• Education Background

          National Taiwan University, B.S. in Chemical Engineering, 2005

          National Taiwan University, M.S. in Chemical Engineering, 2007

          Purdue University, Ph.D. in Chemical Engineering, 2013

• Research Topic

       ● Chromatographic Retention Mechanism and Retention Models

          Liquid chromatography is a widely used separation technique in the pharmaceutical and biotechnology industries. Theoretical models are developed by investigating chromatographic retention behavior. These models not only aid in understanding the retention mechanisms but can also be employed in the design of analytical methods and purification processes.

      ● Chiral Separation

         Enantiomers exhibit distinct pharmacological effects in the human body, making them an important problem of pharmaceutical purification processes. Liquid chromatography is currently the major technique for chiral separations. By investigating the recognition mechanisms, recognition models are proposed and used in the design of chiral separation process.

    ● Simulated Moving Bed

       The development of simulated moving bed (SMB) technology has allowed chromatographic separation processes, originally limited to batch production, to be carried out continuously, resulting in substantial cost reduction in production. We combine experimental and theoretical approaches to explore the design of SMB purification process.

1. Hung-Wei Tsui*, Si-Xian Huang, Ting-Hsien Tseng, "Heterogenous adsorption mechanisms for describing enantioselective retention in normal-phase liquid chromatography," J. Chromatogr. A, 1704, 464140 (2023).
2. Hung-Wei Tsui*, Ching-Hung Hsieh, Chao-Fu Zhan, "Effect of mobile-phase modifiers on the enantioselective retention behavior of methyl mandelate with an amylose 3,5-dimethylphenylcarbamate chiral stationary phase under reversed-phase conditions," J. Sep. Sci., 46, 2200651 (2023).
3. Hung-Wei Tsui*, Song-Zhu Lin, Yu-Chia Hsu, Feng-Ji Dai, "Retention modeling and adsorption mechanisms in reversed-phase liquid chromatography," J. Chromatogr. A, 1662, 462736 (2022).
4. Hung-Wei Tsui*, Hong-Lin Zhang, Ching-Hung Hsieh, "Effect of 2-propanol content on solute retention mechanisms determined using amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase under normal- and reversed-phase conditions," J. Chromatogr. A, 1650, 462226 (2021).
5. Hung-Wei Tsui*, Pei-Wen Ye, Si-Xian Huang, "Effect of solvents on the chiral recognition mechanisms of immobilized cellulose-based chiral stationary phase," J. Chromatogr. A, 1637, 461796 (2021).
6. Hung-Wei Tsui*, Che-Hung Kuo, "Retention and partition behaviors of solutes in a surfactant-based mobile phase at concentrations approaching the critical micelle concentration in liquid chromatography," Chromatographia, 83, 1247–1256 (2020).
7. Hung-Wei Tsui*, Ping-Yi Chou, Pei-Wen Ye, Sin-Chang Chen, Ya-Wen Chen, "Effects of the sorbent backbone and side chain on retention mechanisms using immobilized polysaccharide-based stationary phases in normal phase mode," Chromatographia, 83, 807-819 (2020).
8. Hung-Wei Tsui*, Che-Hung Kuo, Yung-Chen Huang, ”Elucidation of retention behaviors in reversed-phase liquid chromatography as a function of mobile phase composition,” J. Chromatogr. A, 1595, 127-135 (2019).