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台灣大學漁業科學研究所

陳立涵 助理教授

  • 陳立涵 助理教授
  • 經歷:挪威生命科學大學博士

  • 辦公室:漁業科學館305室

  • 聯絡電話:(02)3366-2878

  • 電子郵件:lihanchen@ntu.edu.tw

  • 研究主題:魚類微生物免疫、魚類疫苗、魚類益生菌應用、系統生物學

  • 開設課程:水生生物學
    動物組織學
  •  

研究重點:
一、魚類微生物免疫
(1) 魚類微生物疾病鑑定
(2) 魚類抗病毒免疫機制研究
(3) 魚類抗細菌免疫機制研究
 
二、魚類疫苗研發
(1) 魚類口服疫苗研發
(2) 魚類疫苗新世代佐劑研發
(3) 魚類疫苗抗原生產系統優化
 
三、魚類益生菌應用之研究
(1) 魚類益生菌篩選與建立
(2) 魚類益生菌作用機制研究
(3) 魚類益生菌生產、保存及使用方式之研究
 
四、魚類系統生物學
(1) 以次世代定序及生物資訊建立
(i)     魚類基因體學研究平台
(ii)    魚類轉錄體學研究平台
(iii)   魚類微生物體學研究平台
(2) 融合多體學結果研究魚類免疫系統全貌

       魚類養殖可以提供我們食用魚及觀賞魚,對我們的生活有很大的益處。但是近年因養殖環境及密度的問題,養殖魚類疾病問題嚴重,不僅造成很大的經濟損失,更威脅到許多相關的產業鏈。感染性疾病多為微生物造成,因此只要能夠增強魚體免疫力、控制環境或魚體內中微生物組成,就可以減低微生物感染的問題。但目前我們對魚類免疫及魚類與微生物的交互作用機制仍有許多空白,造成對魚類感染性疾病仍沒有穩定有效的治療策略。
      有鑑於此,我們致力於”全面揭開魚類微生物免疫機制的面紗”。我們研究使用生醫領域最新研究思維及技術,除以次世代定序、生物資訊及基因調控等生物技術,並用系統生物學畫出魚類微生物免疫的全圖外。我們亦將導入最新”微生物相是動物重要器官”的概念,以益生菌介入來調控微生物相進而增強魚體免疫力及強化疫苗效果。
      我們預期將以科學的方式改善魚類養殖病害問題,並減少抗生素及有毒殺菌劑的使用,建立環境友善的養殖方式,讓養殖產業及地球都能擁有永續的未來。

近年重要著作 (2017- ):

責任作者

Ming-Zhen Chen, Li-Yu Su, Pin-Hao Ko, Ming-Hsuan Hsu, Li-Ling Chuang, Li-Han Chen, Tzu-Pin Lu, Eric Y Chuang, Lu-Ping Chow, Mong-Hsun Tsai, Hsao-Hsun Hsu, Liang-Chuan Lai, “Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells”, Int. J. Oncol. 60(2), 1-13, 2022.

LiHan Chen, Shy‐Shin Chang, Hsin‐Yi Chang, Chieh‐Hsi Wu, Chun‐Hsu Pan, Chun‐Chao Chang, Ching‐Hung Chan, Hui‐Yu Huang, “Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice”, J. Cachexia Sarcopenia Muscle 13(1), 515-531, 2022.

Wentao Fang, Chia-Hsin Wu, Qiangling Sun, Zhi-tao Gu, Lei Zhu, Teng Mao, Xue-Fei Zhang, Ning Xu, Tzu-Pin Lu, Mong-Hsun Tsai, Li-Han Chen, Liang-Chuan Lai, Eric Y Chuang, “Novel tumor-specific antigens for immunotherapy identified from multi-omics profiling in thymic carcinomas”, Front. Immunol. 12, 748820, 2021.

Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, and Hui-Yu Huang, “The immunomodulatory effects of long-term supplementation with Lactobacillus casei Shirota depend on ovalbumin presentation in BALB/c mice”, Sci. Rep. 11, 19478, 2021.

Yi-Chun Cheng, Li-Yu Su, Li-Han Chen, Tzu-Pin Lu, Eric Y Chuang, Mong-Hsun Tsai, Li-Ling Chuang, Liang-Chuan Lai, “Regulatory mechanisms and functional roles of hypoxia-induced long non-coding RNA MTORT1 in breast cancer cells”, Front. Oncol. 11, 663114, 2021.

Chung-Hsien Shih, Li-Ling Chuang, Mong-Hsun Tsai, Li-Han Chen, Eric Y Chuang, Tzu-Pin Lu, Liang-Chuan Lai, “Hypoxia-induced MALAT1 promotes the proliferation and migration of breast cancer cells by sponging MiR-3064-5p”, Front. Oncol. 11, 658151, 2021.

Li-Han Chen, Ming-Fu Wang, Chun-Chao Chang, Shih-Yi Huang, Chun-Hsu Pan, Yao-Tsung Yeh, Cheng-Hsieh Huang, Ching-Hung Chan, Hui-Yu Huang, “Lacticaseibacillus paracasei ps23 effectively modulates gut microbiota composition and improves gastrointestinal function in aged samp8 mice”, Nutrients 46, 1116, 2021.

Li-Han Chen, Eric Y. Cuang, “Importance of semaphorins in cancer immunity”, Transl. Lung Cancer Res. 8, S468-S470, 2019. (Impact factor: 4.801, 10/63, Q1)

Li-Han Chen, Che-Yu Liao, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang, “Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis”, Sci. Rep. 9, 13302, 2019. (Impact factor: 4.011, 15/69, Q1

Li-Han Chen, Shih-Yi Huang, Kuo-Chin Huang, Chih-Chieh Hsu, Kuen-Cheh Yang, Lin-Ai Li, Ching-Hung Chan, Hui-Yu Huang, “Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice”, Aging (Albany NY) 11, 756-770, 2019. (Impact factor: 5.515, 5/53, 10%)

Wen-Chun Lin, Li-Han Chen, Yao-Chin Hsieh, Pei-Wen Yang, Liang-Chuan Lai, Eric Y Chuang, Jang-Ming Lee, and Mong-Hsun Tsai, “miR-338-5p inhibits cell proliferation, colony formation, migration and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2”, Carcinogenesis 40(7), 883-892, 2018. (Impact factor: 4.004, 72/229, Q2)

Cheng-Ying Shen, Ya-Chu Chang, Li-Han Chen, Wen-Chun Lin, Yung-Hua Lee, Shu-Tsen Yeh, Hsin-Kuang Chen, Wentao Fang, Chung-Ping Hsu, Jang-Ming Lee, Tzu-Pin Lu, Pei-Wen Hsiao, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang, “The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells”, Oncogenesis 7, 2018. (Impact factor: 5.995, 33/229, Q1)

Shih-Yi Huang, Li-Han Chen, Ming-Fu Wang, Chih-Chieh Hsu, Ching-Hung Chan, Jia-Xian Li, and Hui-Yu Huang, “Lactobacillus paracasei PS23 delays progression of age-related cognitive decline in senescence accelerated mouse prone 8 (SAMP8) mice”, Nutrients 10, 894, 2018. (Impact factor: 4.171, 16/86, Q1) (co-first author)

Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, and Hui-Yu Huang, “ Anti-obesity effect of Lactobacillus Reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high energy diet-fed rats”, J. Nutr. Biochem. 54, 87-94, 2018. (Impact factor: 4.490, 13/86, Q1)

Li-Han Chen, Chia-Chung Hou, Mei-Ling Chang, Ching-Hung Chan, Hung-Wei Tang, and Hui-Yu Huang, “Taiwanese green propolis ethanol extract delays the progression of type 2 diabetes mellitus in rats treated with streptozotocin/high-fat diet”, Nutrients 10, 503, 2018. (Impact factor: 4.171, 16/86, Q1)

Li-Han Chen, Yi-Wen Chien, Chung-Tiang Liang, Ching-Hung Chan, Meng-Han Fan, and Hui-Yu Huang, “ Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat”, Food Nutr. Res. 61(1), 1347480, 2017. (Impact factor: 2.553, 41/135, Q2)