4月 21 日的【午間科學與科技講壇】，感謝蘇南維老師的安排，邀請到臺大醫學院藥理學科暨研究所的魏子堂助理教授，針對黃豆中含量最豐富異黃酮之一的 genistein ，可以弱化大麻引發的血管發炎之效用，發表其研究成果。講題為:
「Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation」
演講安排詳情簡述如下：
【演講時間】2023年4月21日 （週五）中午 12:15-13:20
【地點】農化新館 B10 教室
魏子堂博士於國立臺灣大學藥理學研究所取得博士學位。接著，在「科技部－博士後千里馬計畫」補助下，至美國史丹佛大學心血管中心－Dr. Joseph C. Wu實驗室從事博士後研究，其研究方向主要利用人類誘導多功能幹細胞和動物模型為平台，尋找疾病新穎治療標的和開發新藥。
稍後，魏子堂博士獲得「科技部－愛因斯坦計畫」補助，於2019年進入臺大藥理所擔任助理教授，近年主要探討大麻及大麻素受體於人體不同器官系統的影響。
本次演講內容簡介如下：
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, binds to cannabinoid receptor 1 (CB1/CNR1) in the vasculature and is implicated in CVD. A UK Biobank analysis found that cannabis was an risk factor for CVD. We found that marijuana smoking activated inflammatory cytokines implicated in CVD. In silico virtual screening identified genistein, a soybean isoflavone, as a putative CB1 antagonist. Human-induced pluripotent stem cell-derived endothelial cells were used to model Δ9-THC-induced inflammation and oxidative stress via NF-kB signaling. Knockdown of the CB1 receptor with siRNA, CRISPR interference, and genistein attenuated the effects of Δ9-THC. In mice, genistein blocked Δ9-THC-induced endothelial dysfunction in wire myograph, reduced atherosclerotic plaque, and had minimal penetration of the central nervous system. Genistein is a CB1 antagonist that attenuates Δ9-THC-induced atherosclerosis.
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歡迎各位屆時蒞臨現場聆聽，進行寶貴的學術交流。
文末附上演講海報。
國立臺灣大學生化科技系【午間科學與科技講壇】 敬邀
