NTUBST2019

• 國立台灣大學生命科學院微生物與生化學研究所博士 (1999/09 ~2005/02)
• 國立台灣大學農業化學系碩士 (1997/09 ~ 1999/08)
• 台北醫學大學保健營養學系學士 (1993/09 ~1997/06)

• 建立細胞與動物之肥胖研究平台
• 飲食因子對肥胖造成之代謝異常、免疫調節及癌症發展之影響
• 種子胜肽lunasin生理功能之機制探討

本研究室探討的主題

1. 飲食因子對肥胖相關免疫代謝異常之研究

• 肥胖過程中微環境的改變會吸引多種免疫細胞的浸潤，複雜的細胞激素交互作用，導致免疫調節異常與組織損傷，與數種退化及病理現象息息相關，如:代謝症候群、糖尿病與肺炎感染等。本研究室以細胞或動物肥胖模式來探討飲食因子介入對於抗發炎、免疫與代謝調節之保健功效與其影響機制。

2. 飲食因子對肥胖相關癌症之研究

• 脂肪細胞微環境伴隨異常濃度的細胞激素、生長因子或荷爾蒙等，營造為腫瘤喜好之環境。研究室針對脂肪細胞、免疫細胞與乳腺腫瘤發展之關係，探討飲食因子介入之癌症預防或治療的可能性。

3. 種子胜肽 lunasin 生理功能之研究

• Lunasin為存在大豆及種子之胜肽，已在細胞與動物實驗中發現其抗癌、抗氧化、抗發炎、調節血脂質與神經退化等功能。研究室主要探討lunasin之多元生理功能如: 抗腫瘤、免疫與代謝異常調節等機制，以達到最佳保健功效之應用。

• 國立台灣大學生化科技學系, 教授 (2024/8~now)
• 國立台灣大學生化科技學系, 副教授 (2021/8~2024/7)
• 國立臺灣師範大學生命科學專業學院營養科學學位學程, 副教授 (2018/8 ~ 2021/7)
• 國立臺灣師範大學人類發展與家庭學系營養科學組, 副教授 (2017/8 ~ 2018/7)
• 國立臺灣師範大學人類發展與家庭學系營養科學組, 助理教授 (2013/2 ~ 2017/7)
• 美國賓州匹茲堡大學病理學系, 博士後研究員 (2009/7 ~ 2009/11)
• 美國加州柏克萊大學 營養科學與毒物學系, 博士後研究員 (2007/7 ~ 2012/2)
• 國家衛生研究院 生技與藥物研究所, 博士後研究員 (2005/5 ~ 2007/5)

• 科技部大專校院獎勵特殊優秀人才 (2020)
• 科技部大專校院獎勵特殊優秀人才 (2019)
• 第45屆台灣營養學會 陳尚球教授紀念學術獎 (2019)
• 國立台灣師範大學獎勵卓越教師之優聘教授 (2019)
• 科技部大專校院獎勵特殊優秀人才 (2018)
• 國立台灣師範大學師資生培育金獅獎 (2016)
• 國科會補助大專校院延攬特殊優秀人才 (2013)

1. Huang PY, Chiang CC, Huang CY, Lin PY, Kuo HC, Kuo CH, Hsieh CC*. (2023). Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders. Life Sciences, 333, 122180. (SCI)
2. Huang PY, Hsieh CC* (2023). Immunomodulatory effects of seed peptide lunasin in RAW264.7 macrophages in obese microenvironments. Journal of Functional Foods, 108, 105719. (SCI)
3. Hsieh CC*, Wu CH, Peng SH, Chang CH (2023) Seed-derived peptide lunasin suppressed breast cancer cell growth by regulating inflammatory mediators, aromatase, and estrogen receptors. Food & Nutrition Research. 2023, 67. (SCI)
4. Hsieh CC*, Wang YF, Lin PY, Peng SH, Chou MJ (2021) Seed peptide lunasin ameliorates obesity-induced inflammation and regulates immune responses in C57BL/6J mice fed high-fat diet. Food and Chemical Toxicology, 147, 111908. (SCI)
5. Hsieh CC* (2020). Seed peptide lunasin abates obesity-related inflammation and breast cancer progression. Nutrition Sciences Journal, 44(3):62-69.
6. Hsieh CC*, Chiu HH, Wang CH, Kuo CH (2020) Aspirin modifies inflammatory mediators and metabolomic profiles and contributes to the suppression of obesity-associated breast cancer cell growth. International Journal of Molecular Sciences, 21(13), 4652. (SCI)
7. Chen SI, Tseng HT, Hsieh CC* (2020) Evaluating the impact of soy compounds on breast cancer using data mining approach. Food & Function, 2020, 11(5):4561-4570. (SCI)
8. Chen SI, Hsieh CC* (2019) Chemoprevention by means of soy proteins and peptides: current status and future approaches: A Review. International Journal of Food Science & Technology, 2019, 54:1460-1466. Article ID: IJFS14053. (SCI)
9. Hsieh CC*, Wang CH (2018) Aspirin disrupts the crosstalk of angiogenic and inflammatory cytokines between 4T1 breast cancer cells and macrophages. Mediators of Inflammation, 2018, 6380643. eCollection 2018. (SCI)
10. Chen SI, Hsieh CC* (2018) Why are women with obesity more likely to develop breast cancer. Future Oncology, 14(16):1523-1526. (SCI)
11. Hsieh CC, Martínez-Villaluenga C, de Lumen BO, Hernández-Ledesma B (2018) Updating the research on the chemopreventive and therapeutic role of the peptide lunasin. Journal of the Science of Food and Agriculture, 98(6):2070-2079. (SCI)
12. Hsieh CC*, Peng SH, Chou MJ (2017) Obesity enhances carcinogen 7, 12-Dimethylbenz [a] anthracene -induced tumorigenesis in vitro and in vivo. Food and Chemical Toxicology, 110:156-164. (SCI)
13. Hernández-Ledesma B, Hsieh CC* (2017) Chemopreventive role of food-derived proteins and peptides: a review. Critical Reviews in Food Science and Nutrition, 57(11):2358-2376. (SCI)
14. Hsieh CC*, Chou MJ, Wang CH (2017) Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production. PLoS ONE, 12(2): e0171969. (SCI)
15. Hsieh CC*, Wang CH, Huang YS (2016) Lunasin attenuates obesity-associated metastasis of 4T1 breast cancer cell through anti-inflammatory property. International Journal of Molecular Sciences, 2016, 17(12), pii: E2109. (SCI)
16. Hsieh CC*, (2016) The interaction of obesity and inflammation in breast cancer. Journal of Medical Oncology and Therapeutics, 1(1):15-18.
17. Hsieh CC*, Huang YS (2016) Aspirin breaks the cross-talk between 3T3-L1 adipocytes and 4T1 breast cancer cells by regulating cytokines production. PLoS ONE, 11(1):e0147161. (SCI)
18. Hsieh CC, Hernández-Ledesma B, Fernández-Tomé S, Weinborn V, Barile D, Leite Nobrega de Moura JM (2015) Milk protein, peptides, and oligosaccharides: effects against the 21st century disorders. BioMed Research International, Article ID 146840. (SCI)
19. Chen ML, Hsieh CC, Chiang BL, Lin BF (2015) Triterpenoids and polysaccharide fractions of Ganoderma tsugae exert different effects on anti-allergic activities, Evidence-Based Complementary and Alternative Medicine, Article ID 754836. (SCI)
20. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2013) Chemopreventive properties of peptide lunasin: a review. Protein and Peptide Letters, 20(4):424-432. (SCI)
21. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Chemopreventive role of aspirin and its combinations against cancer. International Journal of Cancer Research and Prevention, 4(4):339-368.
22. Hernández-Ledesma B, Espartosa DM, Hsieh CC, de Lumen BO, Recio I (2011) Role of peptide lunasin’s antioxidant activity on its chemopreventive properties. Annals of Nutrition and Metabolism, 58 (suppl.3):354. (SCI)
23. Hsieh CC, Lin BF (2011) Dietary factors regulate cytokines in murine models of systemic lupus erythematosus. Autoimmunity Reviews, 11(1):22-27. (SCI)
24. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Lunasin-aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens. Plant Foods for Human Nutrition, 66(2):107-113. (SCI)
25. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Cell proliferation inhibitory and apoptosis inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells. Food Chemistry, 125(2):630-636. (SCI)
26. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2011) Relationship between lunasin’s sequence and its inhibitory activity of histones H3 and H4 acetylation. Molecular Nutrition & Food Research, 55(7):989-998. (SCI)
27. Leite Nobrega de Moura JM, Hernández-Ledesma B, de Almeida NM, Hsieh CC, de Lumen BO, Johnson LA (2011) Lunasin and Bowman-Birk protease inhibitor concentrations of protein extracts from enzyme-assisted aqueous extraction of soybeans. Journal of Agricultural and Food Chemistry, 59(13):6940-6946. (SCI)
28. Jeong HJ, Jeong JB, Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies. Nutrition and Cancer - An International Journal, 62(8):1113-1119.
29. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Soybean peptide lunasin suppresses in vitro and in vivo 7,12-dimethylbenz[a]anthracene-induced tumorigenesis. Journal of Food Science, 75(9):H311-H316. (SCI)
30. Hsieh CC, Hernández-Ledesma B, de Lumen BO (2010) Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced-apoptosis. Chemico-Biological Interactions, 186(2):127-134. (SCI)
31. Hsieh CC, Hernández-Ledesma B, Jeong HJ, Park JH, de Lumen BO (2010) Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PLoS ONE, 5(1):e8890. (SCI)
32. Hernández-Ledesma B, Hsieh CC^# (equal contribution), de Lumen BO (2009) Anti-inflammatory and antioxidant properties of peptide lunasin in RAW 264.7 macrophages. Biochemical and Biophysical Research Communications, 390(3):803-808. (SCI)
33. Hernández-Ledesma B, Hsieh CC, de Lumen BO (2009) Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods. Food Chemistry, 115 (2):574-580. (SCI)
34. Hernández-Ledesma B, Hsieh CC^# (equal contribution), de Lumen BO (2009) Lunasin, a novel peptide for cancer prevention. Peptides, 30(2):426-430. (SCI)
35. Tai CL, Hung MS, Pawar VD, Tseng SL, Song JS, Hsieh WP, Chiu HH, Wu HC, Hsieh MT, Kuo CW, Hsieh CC, Tsao JP, Chao YS, Shia KS (2008) Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists. Organic & Biomolecular Chemistry, 6(3):447-450. (SCI)
36. Hsieh CC, Huang CJ, Lin BF (2006) Low and high levels of a-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPARg, IkBa and apoptotic pathway in activated splenocytes. Nutrition, 22(4):433-440. (SCI)
37. Hsieh CC, Lin BF (2005) Opposite effects of low- and high-dose supplementation of vitamin E on survival of MRL/lpr mice. Nutrition, 21(9):940-948. (SCI)
38. Hsieh CC, Lin BF (2005) The effects of vitamin E supplementation on autoimmune-prone New Zealand black ´ New Zealand white F1 mice fed an oxidised oil diet. British Journal of Nutrition, 93(5):655-662. (SCI)
39. Chen ML, Hsieh CC, Chen KJ, Lin BF (2004) Association between abdominal skin fold and daily fluid intake in young adults. Nutrition Sciences Journal, 29(4): 237-243.