NTUBST2019

• 英國劍橋大學 生物化學系 博士 (1993~1997)
• 國立台灣大學 農業化學系 碩士 (1991 ~ 1993)
• 國立台灣大學 農業化學系 學士 (1985 ~ 1989)

The GREEN Lab

• 植物中許多未知功能基因，可能在植物逆境下才看到其功能。研究這些基因對糧食安全奠定發展方向的基礎。我們優先放在未知功能研究的基因，是考慮其轉譯出的蛋白，從蛋白化學的角度具有新而有趣，或具挑戰性的蛋白，包括膜蛋白，血基質蛋白，大蛋白複合體，具 “無結構區塊”蛋白 (IDP)，新穎轉錄因子等。
• 我們利用生物化學，生物資訊，功能性基因體，遺傳學，細胞學等方法探索這些植物未知功能基因之功能。此外蛋白結構分子模擬與系統生物學，在實驗室中作為分析蛋白結構與功能關係之方法。
• Using Genomic and proteomic tools to probe the Regulatory mechanism of plants in response to Environmental stresses: From Evolution to Next GREEN revolution

• 生化科技學系 教授 (2016/8 ~ now)
• 生化科技學系 系主任 (2019/08 ~ 2022/07)
• 生化科技學系 代理系主任 (2019/02 ~ 2019/07)
• 生化科技學系 副教授 (2010/8 ~ 2016/7)
• 生化科技學系 助理教授 (2003 ~ 2010/7)
• 微生物與生化學研究所 助理教授 (2003 ~ 2010/7)
• 農業化學系 助理教授 (1999 ~ 2003)
• CNRS-CEA Institut de Biologie Stucturale, Grenoble, France 博士後研究 (1998 ~ 1999)
• 劍橋大學生物化學系 博士後研究 (1997 ~ 1998)

1. Chen Hsu , Hsin-Ya Tsai, Chi-Fon Chang , Chien-Chih Yang, Nan-Wei Su (2022, Aug). Discovery of a novel phosphotransferase from Bacillus subtilis that phosphorylates a broad spectrum of flavonoids. Food Chem.,https://doi.org/10.1016/j.foodchem.2022.134001.(SCI)
2. Liao HS, Yang CC, Hsieh MH. Nitrogen deficiency- and sucrose-induced anthocyanin biosynthesis is modulated by HISTONE DEACETYLASE15 in Arabidopsis. J Exp Bot 2022.(SCI)
3. Chen EH, Weng CW, Li YM, Wu MC, Yang CC, Lee KT, Chen RP, Cheng CP. De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens. Front Plant Sci 2021; 12: 753217.(SCI)
4. Wang YJ, Lee SC, Hsu CH, Kuo YH, Yang CC, Lin FJ. Antcins, triterpenoids from Antrodia cinnamomea, as new agonists for peroxisome proliferator-activated receptor alpha. J Food Drug Anal 2019; 27(1): 295-304.(SCI)
5. Shen HC, Chen YH, Lin YS, Chu BK, Liang CS, Yang CC, Chen RP. Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils. Neurochem Res 2019; 44(6): 1399-409.(SCI)
6. Huang YC, Hsiang EC, Yang CC, Wang AY. New insight into the catalytic properties of rice sucrose synthase. Plant Mol Biol 2015; 90(1-2):127-35.(SCI)
7. Liang CH, Yang CC. Identification of ICE1 as a negative regulator of ABA-dependent pathways in seeds and seedlings of Arabidopsis. Plant Mol Biol 2015; 88(4-5): 459-70.(SCI)
8. Hsieh YL, Lu CF, Chiang BY, Liao SC, Chen RY, Lin CS, Wang AY, Yang CC. Molecular Characterization of Ethylene Response Sensor 1 (BoERS1) in Bambusa oldhamii. Plant Mol Biol Rep 2015: 1-12.(SCI)
9. Yeh SH, Lee BH, Liao SC, Tsai MH, Tseng YH, Chang HC, Yang CC, Jan HC, Chiu YC, Wang AY. Identification of genes differentially expressed during the growth ofBambusa oldhamii. Plant Physiol Biochem 2013; 63: 217-26.(SCI)
10. Chia JC, Yang CC, Sui YT, Lin SY, Juang RH. Tentative identification of the second substrate binding site in Arabidopsis phytochelatin synthase. PLoS ONE 2013; 8(12): e82675.(SCI)
11. Kao AL, Lin YH, Chen RP, Huang YY, Chen CC, Yang CC. E3-independent ubiquitination of AtMAPR/MSBP1. Phytochemistry. 2012; 78: 7-19. (SCI)
12. Hsieh LS, Hsieh YL, Yeh CS, Cheng CY, Yang CC, Lee PD. Molecular characterization of a phenylalanine ammonia-lyase gene (BoPAL1) from Bambusa oldhamii. Mol Biol Rep. 2011; 38(1): 283-90. (SCI)
13. Chang JC, Liao YC, Yang CC, Wang AY. The purine-rich DNA binding protein OsPuralpha participates in the regulation of the rice sucrose synthase 1 gene expression.Physiol Plant. 2011. (SCI)
14. Hsieh LS, Yeh CS, Pan HC, Cheng CY, Yang CC, Lee PD. Cloning and expression of a phenylalanine ammonia-lyase gene (BoPAL2) from Bambusa oldhamii in Escherichia coli and Pichia pastoris. Protein Expr Purif. 2010; 71(2): 224-30. (SCI)
15. Hsieh LS, Ma GJ, Yang CC, Lee PD. Cloning, expression, site-directed mutagenesis and immunolocalization of phenylalanine ammonia-lyase in Bambusa oldhamii.Phytochemistry. 2010; 71(17-18): 1999-2009. (SCI)
16. Chen CY, Hsieh MH, Yang CC, Lin CS, Wang AY. Analysis of the cellulose synthase genes associated with primary cell wall synthesis in Bambusa oldhamii.Phytochemistry. 2010; 71(11-12): 1270-9. (SCI)
17. Chen CC, Liang CS, Kao AL, Yang CC. HHP1, a novel signalling component in the cross-talk between the cold and osmotic signalling pathways in Arabidopsis. J Exp Bot. 2010; 61(12): 3305-20. (SCI)
18. Wang HC, Wu JS, Chia JC, Yang CC, Wu YJ, Juang RH. Phytochelatin synthase is regulated by protein phosphorylation at a threonine residue near its catalytic site. J Agric Food Chem. 2009; 57(16): 7348-55. (SCI)
19. Ho CC, Lee LY, Huang KT, Lin CC, Ku MY, Yang CC, Chan SI, Hsu RL, Chen RP. Tuning the conformational properties of the prion peptide. Proteins. 2009; 76(1): 213-25. (SCI)
20. Chen TH, Huang YC, Yang CS, Yang CC, Wang AY, Sung HY. Insights into the catalytic properties of bamboo vacuolar invertase through mutational analysis of active site residues. Phytochemistry. 2009; 70(1): 25-31. (SCI)
21. Chen CC, Liang CS, Kao AL, Yang CC. HHP1 is involved in osmotic stress sensitivity in Arabidopsis. J Exp Bot. 2009; 60(6): 1589-604. (SCI)
22. Kao AL, Chang TY, Chang SH, Su JC, Yang CC. Characterization of a novel Arabidopsis protein family AtMAPR homologous to 25-Dx/IZAg/Hpr6.6 proteins. Bot Bul Acad Sin. 2005; 46(2): 107-18. (SCI)
23. Lai CP, Lee CL, Chen PH, Wu SH, Yang CC, Shaw JF. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 2004; 134(4): 1586-97. (SCI)
24. Hsu JH, Yang CC, Su JC, Lee PD. Purification and characterization of a cytosolic starch phosphorylase from etiolated rice seedlings. Bot Bul Acad Sin. 2004; 45(3): 187-96. (SCI)
25. Chen PY, Gopalacushina BG, Yang CC, Chan SI, Evans PA. The role of a beta-bulge in the folding of the beta-hairpin structure in ubiquitin. Protein Sci. 2001; 10(10): 2063-74. (SCI)
26. Yang CC, Packman LC, Scrutton NS. The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition. Eur J Biochem. 1995; 232(1): 264-71. (SCI)
27. Raine AR, Yang CC, Packman LC, White SA, Mathews FS, Scrutton NS. Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands. Protein Sci. 1995; 4(12): 2625-8. (SCI)