Institute of Fisheries Science, NTU

Research Interests:

1. Fish microbial immunity
(1) Identification of fish microbial diseases
(2) Mechanism of fish anti-pathogen immunity
 
2. Fish vaccines
(1) Development of oral vaccines for fish
(2) Research and development of new generation adjuvants for fish vaccines
(3) Optimization of fish vaccine antigen production system
 
3. Fish probiotics
(1) Selection of fish probiotics
(2) Effect and mechanism of fish probiotics in fish immunity
 
4. Fish systems biology
(1) Establishment of
     (i)   Fish genomics research platform
     (ii)  Fish transcriptology research platform
     (iii) Fish microbiology research platform
(2) Investigating overall picture of fish immune system

Aquaculture provides us ornamental fish and high quality food, which is of great benefit to our lives in the decades. However, the problems of aquatic diseases are more and more serious, which not only cause great economic losses, but also threaten the related industry chain.
Imbalance of immunity and microorganisms is one of the most important factors leading diseases. Therefore, understanding the interactions of immunity and microorganisms in fish can establish a solid foundation for the preventing and therapeutic strategy of fish disease.
In the light of this, our lab focus on demystifying the mechanism of fish microbial immunity. We use the latest research thinking and technology in systems biology and bioinformatics to draw a complete picture of fish microbial immunity. We also introduce the concept of  "microbiome as an organ of animals" to our research, thus regulating the microbiota by probiotics to enhance the immunity of fish and efficacy of vaccine. We expect to resolve the issues of aquatic diseases in an eco-friendly way by reducing the use of antibiotics and toxic drugs in the near future.
 

近年重要著作 (2017- ):

責任作者

Ming-Zhen Chen, Li-Yu Su, Pin-Hao Ko, Ming-Hsuan Hsu, Li-Ling Chuang, Li-Han Chen, Tzu-Pin Lu, Eric Y Chuang, Lu-Ping Chow, Mong-Hsun Tsai, Hsao-Hsun Hsu, Liang-Chuan Lai, “Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells”, Int. J. Oncol. 60(2), 1-13, 2022.

Li‐Han Chen, Shy‐Shin Chang, Hsin‐Yi Chang, Chieh‐Hsi Wu, Chun‐Hsu Pan, Chun‐Chao Chang, Ching‐Hung Chan, Hui‐Yu Huang, “Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice”, J. Cachexia Sarcopenia Muscle 13(1), 515-531, 2022.

Wentao Fang, Chia-Hsin Wu, Qiangling Sun, Zhi-tao Gu, Lei Zhu, Teng Mao, Xue-Fei Zhang, Ning Xu, Tzu-Pin Lu, Mong-Hsun Tsai, Li-Han Chen, Liang-Chuan Lai, Eric Y Chuang, “Novel tumor-specific antigens for immunotherapy identified from multi-omics profiling in thymic carcinomas”, Front. Immunol. 12, 748820, 2021.

Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, and Hui-Yu Huang, “The immunomodulatory effects of long-term supplementation with Lactobacillus casei Shirota depend on ovalbumin presentation in BALB/c mice”, Sci. Rep. 11, 19478, 2021.

Yi-Chun Cheng, Li-Yu Su, Li-Han Chen, Tzu-Pin Lu, Eric Y Chuang, Mong-Hsun Tsai, Li-Ling Chuang, Liang-Chuan Lai, “Regulatory mechanisms and functional roles of hypoxia-induced long non-coding RNA MTORT1 in breast cancer cells”, Front. Oncol. 11, 663114, 2021.

Chung-Hsien Shih, Li-Ling Chuang, Mong-Hsun Tsai, Li-Han Chen, Eric Y Chuang, Tzu-Pin Lu, Liang-Chuan Lai, “Hypoxia-induced MALAT1 promotes the proliferation and migration of breast cancer cells by sponging MiR-3064-5p”, Front. Oncol. 11, 658151, 2021.

Li-Han Chen, Ming-Fu Wang, Chun-Chao Chang, Shih-Yi Huang, Chun-Hsu Pan, Yao-Tsung Yeh, Cheng-Hsieh Huang, Ching-Hung Chan, Hui-Yu Huang, “Lacticaseibacillus paracasei ps23 effectively modulates gut microbiota composition and improves gastrointestinal function in aged samp8 mice”, Nutrients 46, 1116, 2021.

Li-Han Chen, Eric Y. Cuang, “Importance of semaphorins in cancer immunity”, Transl. Lung Cancer Res. 8, S468-S470, 2019. (Impact factor: 4.801, 10/63, Q1)

Li-Han Chen, Che-Yu Liao, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang, “Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis”, Sci. Rep. 9, 13302, 2019. (Impact factor: 4.011, 15/69, Q1

Li-Han Chen, Shih-Yi Huang, Kuo-Chin Huang, Chih-Chieh Hsu, Kuen-Cheh Yang, Lin-Ai Li, Ching-Hung Chan, Hui-Yu Huang, “Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice”, Aging (Albany NY) 11, 756-770, 2019. (Impact factor: 5.515, 5/53, 10%)

Wen-Chun Lin, Li-Han Chen, Yao-Chin Hsieh, Pei-Wen Yang, Liang-Chuan Lai, Eric Y Chuang, Jang-Ming Lee, and Mong-Hsun Tsai, “miR-338-5p inhibits cell proliferation, colony formation, migration and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2”, Carcinogenesis 40(7), 883-892, 2018. (Impact factor: 4.004, 72/229, Q2)

Cheng-Ying Shen, Ya-Chu Chang, Li-Han Chen, Wen-Chun Lin, Yung-Hua Lee, Shu-Tsen Yeh, Hsin-Kuang Chen, Wentao Fang, Chung-Ping Hsu, Jang-Ming Lee, Tzu-Pin Lu, Pei-Wen Hsiao, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang, “The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells”, Oncogenesis 7, 2018. (Impact factor: 5.995, 33/229, Q1)

Shih-Yi Huang, Li-Han Chen, Ming-Fu Wang, Chih-Chieh Hsu, Ching-Hung Chan, Jia-Xian Li, and Hui-Yu Huang, “Lactobacillus paracasei PS23 delays progression of age-related cognitive decline in senescence accelerated mouse prone 8 (SAMP8) mice”, Nutrients 10, 894, 2018. (Impact factor: 4.171, 16/86, Q1) (co-first author)

Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, and Hui-Yu Huang, “ Anti-obesity effect of Lactobacillus Reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high energy diet-fed rats”, J. Nutr. Biochem. 54, 87-94, 2018. (Impact factor: 4.490, 13/86, Q1)

Li-Han Chen, Chia-Chung Hou, Mei-Ling Chang, Ching-Hung Chan, Hung-Wei Tang, and Hui-Yu Huang, “Taiwanese green propolis ethanol extract delays the progression of type 2 diabetes mellitus in rats treated with streptozotocin/high-fat diet”, Nutrients 10, 503, 2018. (Impact factor: 4.171, 16/86, Q1)

Li-Han Chen, Yi-Wen Chien, Chung-Tiang Liang, Ching-Hung Chan, Meng-Han Fan, and Hui-Yu Huang, “ Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat”, Food Nutr. Res. 61(1), 1347480, 2017. (Impact factor: 2.553, 41/135, Q2)