Institute of Fisheries Science, NTU

Occurrence of diseases of aquaculture animals were initiated by a complex factor including pathogenic and non-pathogenic (or environmental) factors.  It is not easy to control the fish or shrimp mortality simply using drugs.
In the past forty years, my research works mainly focalized on the studies on the production of mushroom Beta-Glucans and their applications on the control of aquaculture animals.  We have successfully used mushroom Beta-Glucan to enhance the immunity for cultured animals so that the survival for cultured animals may significantly upgraded.  Consequently, mass mortality for aquatic cultured animals such as shrimps and fish may be controlled.  In addition to Beta-Glucan, my Lab. also developed a system in using of beneficial bacteria to control the organic pollution or deterioration for aquaculture pond so that successful cultured system can be comparatively anticipated.

近年重要著作 (2010- ):

Yu-Sheng Wu, Shu-Ying Ho, Fan-Hua Nan and Shiu-Nan Chen (2016) Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet. BMC Complementary and Alternative Medicine.

Wu Y-S and Chen S-N (2016), Extracted Triterpenes from Antrodia cinnamomea Reduce the Inflammation to Promote the wound Healing via the STZ Inducing Hyperglycemia- Diabetes Mice Model. Frontiers in Pharmacology, June 2016/ Volume 7/ Article 154

Wu Y-S and Chen S-N (2016), Triterpenes Reduce the Hyperglycemia-Diabetes Mice Inflammation. Frontiers in Pharmacology, June 2016/ Volume 7/ Article 154

Chien-Mei Hsiao, Yu-Sheng Wu, Fan-Hua Nan, Shih-Ling Huang, Lynette Chen and Shiu-Nan Chen (2015) Immunomodulator ‘mushroom beta glucan’ induces Wnt/ß catenin signaling and improves wound recovery in tilapia and rat skin: a histopathological study  International Wound Journal ISSN 1742-4801, 1-13.

Chih-Chiu Yang, Chung-Lun Lua, Sherwin Chen, Wen-Liang Liao and Shiu-Nan Chen (2015) Immune gene expression for diverse haemocytes derived from pacific white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology,  Volume 44, 265-271

Chih-Chiu Yang, Chung-Lun Lu, Sherwin Chen, Kam-Chiu Lai1, Wen-Liang Liao and Shiu-Nan Chen (2014) Effect of Mushroom Beta Glucan (MBG) on Immune and Haemocyte Response in Pacific White Shrimp (Litopenaeus vannamei).  Journal of Aquaculture Research & Development, Volume 5:275

Wan-Jhen Wang, Yu-Sheng Wu, Sherwin Chen, Chi-Feng Liu, and Shiu-Nan Chen, (2014)  Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma
Hindawi Publishing Corporation, BioMed Research International, Volume 2014, Article ID 604385, 1 - 15  (SCI)

Yu-Sheng Wu, Shih-Ling Huang, Fan-Hua Nan, Ching-Sheng Chang, Chien-Mei Hsiao, Kam-Chiu Lai and Shiu-Nan Chen. (2014)  Over-inhibition of NADPH oxidase reduce the wound healing in liver of finfish,
Fish & Shellfish Immunology, Volume 40, 174 – 181

Shiu-Nan Chen, Ching-Sheng Chang, Ming-Hsin Hung, Sherwin Chen, William Wang, Cheng-Jeng Tai, and Chung-Lun Lu, (2014)  The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis
Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 252171, 1 – 7  (SCI)

Yu-Sheng Wu, Sherwin Chen, William Wang, Chung-Lun Lu, Chi-Feng Liu, and Shiu-Nan Chen. (2014)  Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model
Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 567427, 1 - 9  (SCI)

Yu-Sheng Wu, Fan-Hua Nan, Shih-Ling Huang, Chien-Mei Hsiao, Kam-Chiu Lai, Chung-Lun Lu and Shiu-Nan Chen. (2014)  Studies of Macrophage Cellular Response to the Extracellular Hydrogen peroxide by Tilapia Model,
Fish & Shellfish Immunology, Volume 36, 459 – 466  (SCI)

Yu-Sheng Wu and Shiu-Nan Chen (2014)  Apoptotic cell: Linkage of Inflammation and Wound Healing,  Frontiers in Pharmacology, Volume 5, 1 - 6

Yu-Sheng Wu and Shiu-Nan Chen (2013)  Inflammation and Carcinogenesis,
Journal of cancer therapy, Volume 4, 1449-1451 (SCI)

Ching-Sheng Chang and Shiu-Nan Chen, (2013) Efficacy of Using Schizophyllan on Innate Immune Responses and Disease Resistant of Epinephelus coioides,  Journal of Fish Soc. Taiwan, 2013, 40(4): 219–229

Shiue-Lian Lin, and Shiu-Nan Chen, (2013) Establishing a Cell Line from Apolemichthys trimaculatus Fins,  Journal of Fish Soc. Taiwan, 2013, 40(2): 107–116

S.-L. Lin, Y.-H. Cheng, C.-M. Wen, and S.-N. Chen, (2013)
Characterization of a novel cell line from the caudal fin of koi carp Cyprinus carpio, Journal of Fish Biology, Volume 82(6):1888–1903  (SCI)

Ching-Sheng Chang, Shih-Ling Huang, Sherwin Chen, and Shiu-Nan Chen, (2013)  Innate Immune Responses and Efficacy of Using Mushroom Beta-Glucan Mixture (MBG) on Orange-spotted Grouper, Epinephelus coioides, aquaculture
Fish & Shellfish Immunology, Volume 35, 115–125  (SCI)

Chih-Hui Lu, Chen-Chun Ku, Chiu-Ming Wen and Shiu-Nan Chen, (2012)
Effects of the Gill Parasite Zeuxapta seriolae (Monogenea: Heteraxinidae) on the Sea Cage-cultured Amberjack Seriola dumerili (Risso, 1810) at Penghu Island (Pescadores), Taiwan  J. Fish. Soc. Taiwan, Volume 39(2): 107–114

Chen, S. N., F. H. Nan, S. Chen, J. F. Wu, C. L. Lu, and Madhu G. Soni, (2011).
Safety assessment of mushroom ß-glucan: Subchronic toxicity in rodents and mutagenicity studies.  Food and Chemical Toxicology, 49, 2890-2898. (SCI)

Chou, Y.Y., Chun-Shun Wang, Hui-Guan Chen, Hui-Yu Chen, Shiu-Nan Chen, and Hsiu-Hui Shih, (2011). Parasitism between Anisakis simplex (Nematoda: Anisakidae) third-stage larvae and the spotted mackerel Scomber australasicus with regard to the application of stock identification.  Veterinary Parasitology, Volume 177, 324-331. (SCI)

Chen, H.G., Hui-Yu Chen, Chun-Shun Wang, Shiu-Nan Chen, and Hsiu-Hui Shih, (2010).
Effects of various treatments on egg hatching of Dendromonocotyle pipinna (Monogenea: Monocotylidae) infecting the blotched fantail ray, Taeniurops meyeni, in Taiwan. 
Veterinary Parasitology, Volume 171, 229-237. (SCI)

Lu, C. L., J. P. Wang, and S. N. Chen^*, (2010) Protease Purified from Schizophyllum commune Culture Broth Digests Fibrins without Activating Plasminogen. The American Journal of Chinese Medicine, 38, No. 6, 1223-1231. (SCI)

Lu, C.L., and Shiu-Nan Chen^*, (2010) Magnesium Enhanced Fibrinolytic Activity of Protease from Schizophyllum commune.  Taiwania, 55, No. 2, 117-122.

Lu, C. L., Sherwin Chen, and S. N. Chen^*, (2010)
Purification and Characterization of a Novel Fibrinolytic Protease from Schizophyllum commune.  Journal of Food and Drug Analysis, 18, No. 2, 69-76. (SCI)