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Institute of Fisheries Science, NTU

Chin-I Chang Professor

  • Chin-I Chang


  • Education:Ph. D., Zoology Department, Scottish Fish Immunology Research Centre, University of Aberdeen, U.K.

  • Office:Fisheries Research Institute, COA

  • TEL:(02)2463-3100
  • (02)2462-5259 (FAX)


  • Course:Fish Diseases, Fish Immunology, Aquatic Bio-technology

Research Interests:
(1) Fish Diseases
(2) Fish Immunology
(3) Aquatic Bio-technology


張錦宜 (2012) 生菌數檢測方法及其檢測套組。中華民國發明專利 (發明第 I 363095號),專利權期間:自2012年5月1日至2028年10月30日。


技術移轉 (Technology Transfer)

朱惠真、張錦宜、陳力豪 (2017/6 ~ 2022/5) 技術名稱:「腸炎弧菌池邊即時快檢套組」,移轉公司:「全興國際水產股份有限公司」.

(Vibrio parahaemolyticus fast detecting strip, VP-kit)

張錦宜 (2014/11 ~ 2019/10) 技術名稱:「水產病原快速檢測試劑-水產病原性弧菌檢測套組」,移轉公司:「全興國際水產股份有限公司」.

(Multiple Vibrio detecting kit, MV-kit)

張錦宜 (2007/4 ~ 2010/4) 技術名稱:「鰻魚潰瘍症病原菌藥物敏感性檢測套組」,移轉公司:「晶宇生物技術實業股份有限公司」.

(Fast susceptibility assay kit for Edwardsiella tarda )

張錦宜 (2006/5 ~ 2009/5) 技術名稱:「鰻魚潰瘍症病原菌快速檢測套組」,移轉公司:「晶宇生物技術實業股份有限公司」.

(Fast detecting kit for Edwardsiella tarda)

近年重要著作 :

C. -I. Chang, L.-H. Chen, Y.-F. Hu, C.-C. Wu, J.-M. Tsai (2017) Determining the cleavage site for the mature antimicrobial peptide of Nile tilapia β-defensin using 2D electrophoresis, Western blot, and mass spectrometry analysis. Fish & Shellfish Immunology, 62: 41-46 (SCI).
O. Byadgi, C. -I. Chang, J. -W. Lee, C. -C. J. Huang and T. -C. Cheng (2016) Immunostimulatory effects of non-CpG oligodeoxynucleotides on cobia (Rachycentron canadum). Aquaculture International, 24: 595-608 (SCI)
L. -H. Chen, S. -W. Lin, K. -F. Liu, C. -I. Chang, J. -R. Hseu and J. -M. Tsai (2016) Comparative proteomic analysis of Litopenaeus vannamei gills after vaccination with two WSSV structural proteins. Fish & Shellfish Immunology, 49: 306-314 (SCI).
朱惠真、黃美瑩、劉旭展、曾亮瑋、潘崇良、張錦宜 (2016) 自海水魚蝦篩選抗水產病原弧菌之拮抗菌。水產研究,24(1): 37-50。
黃美瑩、朱惠真、陳力豪、劉旭展、曾亮瑋、潘崇良、張錦宜 (2016) 飼料中添加益生菌Bacillus pumilus D5對於白蝦成長、免疫反應及抗腸炎弧菌效率之影響。水產研究,24(2): 57-69。
M.-Y. Huang, C. -I. Chang, C. -C. Chang,  L. -W. Tseng and C. -L. Pan (2015) Effects of dietary levan on growth performance, nonspecific immunity, pathogen resistance and body composition of orange-spotted grouper (Epinephelus coioides H.). Aquaculture Research, 46: 2752-2767 (SCI).
C. -I. Chang, C. -F. Lee, J. -M. Tsai, C. -C. Wu, L. -H Chen, S. -C. Chen and K. -J. Lin (2014) Development of a selective and differential medium for capsulated Lactococcus garvieae. Journal of Fish Diseases, 37: 719-728 (SCI).
Y. -T Liu, C. -I Chang, J. -R. Hseu, K. -F. Liu and J. -M. Tsai (2013) Immune  responses of prophenoloxidase and cytosolic manganese superoxide dismutase in the freshwater crayfish Cherax quadricarinatus against a virus and bacterium. Molecular Immunology, 56: 72-80 (SCI).
C. -I. Chang, P. -H. Hung, C. -C. Wu, T. C. Cheng, J. -M. Tsai, K. -J. Lin and C. -Y. Lin (2012) Simultaneous Detection of Multiple Fish Pathogens Using a Naked-Eye Readable DNA Microarray. Sensors, 12: 2710-2728 (SCI).
J. -Y Yang, C. -I Chang, K. -F. Liu, J. -R. Hseu, L. -H. Chen and J. -M. Tsai (2012) Viral resistance and immune responses of the shrimp Litopenaeus  vannamei vaccinated by two WSSV structural proteins. Immunology Letters, 148: 41-48 (SCI).
C. -I. Chang, C. -F. Lee, C. -C. Wu, T. C. Cheng, J. -M. Tsai and K. -J. Lin (2011) A selective and differential medium for Vibrio alginolyticus. Journal of Fish Diseases, 34: 227-234(SCI).
T. C. Cheng, K. S. Yao, N. Yeh, C. -I. Chang, H. C. Hsu, F. Gonzalez and C. Y. Chang (2011) Bactericidal effect of blue LED light irradiated TiO2/Fe3O4 particles on fish pathogen in seawater. Thin Solid Films, 519: 5002-5006(SCI).
C-I. Chang, C. -C. Wu,  T. C. Cheng, J. -M. Tsai and K. -J. Lin (2009) Multiplex nested-polymerase chain reaction for the simultaneous detection of Aeromonas hydrophila, Edwardsiella tarda, Photobacterium damselae and Streptococcus iniae, four important fish pathogens in subtropical Asia. Aquaculture Research, 40: 1182-1190 (SCI).
陳力豪、胡鄴方、朱惠真、吳嘉哲、張錦宜 (2015) 尼羅吳郭魚抗菌胜肽β-防禦素之基因選殖與分子特性研究. 水產研究. 23(1): 35-47.
張錦宜, 黃美瑩, 吳嘉哲, 林富家, 王文政, 林金榮 (2009) 台東附近海域不同深度海水中的好氣及兼氣性異營細菌組成. 水產研究. 17(1): 25-38.
T.C. Cheng, K.S. Yao, N. Yeh, C.I. Chang, H.C. Hsu, Y.T. Chien and C.Y. Chang  (2009) Visible light activated bactericidal effect of TiO2/Fe3O4 magnetic particles on fish pathogens. Surface & Coatings Technology, 204: 1141-1144 (SCI).
J.-J. Guo, K.-F. Liu, S.-H. Cheng, C.-I. Chang, J.-J. Lay, Y.-O. Hsu, J.-Y. Yang, T.-I. Chen (2009) Selection of probiotic bacteria for use in shrimp larviculture. Aquaculture Research, 40: 609-618 (SCI).
T.C. Cheng, C.Y. Chang, C.I. Chang, C.J. Hwang, H.C. Hsu, D.Y. Wang and K.S. Yao (2008) Photocatalytic bactericidal effect of TiO2 thin film on fish pathogens. Surface & Coatings Technology, 203: 925-927 (SCI).
黃美瑩, 張錦宜, 張慎恩, 洪珮馨, 林金榮 (2007) 深層海水中乳酸菌的分離與鑑定. 水產研究. 15: 45-54.
C. -I. Chang, Y. -A. Zhang, J. Zou, P. Nie and C. J. Secombes (2006) Two cathelicidin genes are present in both rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar. Antimicrob. Agents Chemother. 50: 185-195.
C. -I. Chang, O. Pleguezuelos, Y. -A. Zhang, J. Zou and C. J. Secombes (2005) Identification of a novel cathelicidin gene in rainbow trout Oncorhynchus mykiss. Infect. Immun. 73: 5053-5064.
Y. -A. Zhang, J. Zou, C. -I. Chang and C. J. Secombes (2004) Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout. Vet. Immunol. Immunopathol. 101: 259-269.
C. I. Chang and W. Y. Liu (2002) An evaluation of two probiotics bacterial strains, Enterococcus faecium SF68 and Bacillus toyoi, for reducing edwardsiellosis in cultured European eel Anguilla anguilla L. J. Fish Dis. 25: 311-315.
C. I. Chang, W. Y. Liu and C. Z. Shyu (2000) Use of prawn blood agar hemolysis to screen for bacteria pathogenic to cultured tiger prawns Penaeus monodon. Dis. Aquat. Org. 43: 153-157.
張錦宜, 徐崇仁 (1998) 五種藥物對歐洲鰻(Anguilla anguilla)感染擬指環蟲(Pseudodactylogyrus spp.)症之療效比較. 中國水產, 552: 3-16.
張錦宜, 徐崇仁 (1997) 氨作為養殖系統中生物濾床之制菌劑的可行性探討. 水產研究, 5(1): 51-60.
張錦宜, 李武忠, 陳淑鈴, 徐崇仁 (1997) 飼料中添加幾丁質對斑節蝦成長及免疫力之影響. 水產研究, 5(1): 11-19.
張錦宜, 李武忠, 徐崇仁, 廖一久 (1996) 檢測細菌對蝦類溶血活性之蝦血培養基之研發. 中華微免雜誌, 29: 232-239.
C. -I. Chang, H. Y. Chung and G. H. Kou (1996) Numerical Taxonomy of bacteria isolated from the hepatopancreas of giant tiger prawn Penaeus monodon, fleshy prawn P. chinensis, and their culture water. J. Fish. Soc. Taiwan, 23(2): 117-136.
研討會論文 (Conference)
M. Y. Huang, H. J. Ju, L. W. Tseng and C. -I. Chang (2017) Antibacterial activity on aquatic pathogens of recombinant antimicrobial peptides from Yarrowia lipolytica. 2017 International Conference on Functional Food for Metabolic Homeostasis in Aging. Mar. 10, Providence University, Taichung, Taiwan, p.44.
P. H. Chen, H. J. Chai and C. -I. Chang (2017) Studies on the osteogenic action of enzymatic extracts from Eucheuma serra. The 10th International Conference and Exhibition on Nutraceuticals & Functional Foods (ISNFF 2017). Oct. 22-25, GSCO, Gunsan, Korea.
C. -I. Chang, C. H. Sung and C. -Y. Lin (2016) The integrated planning to develop green energy, biochar and waste recirculation technology in agriculture. The 1st International Conference on Intelligent Agricultural Machinery in Taiwan. Yunlin, Taiwan, 21th~22th Oct. 2016.
C. -I. Chang and Y. -F. Hu (2015) Status and prospects of aquaculture in Taiwan. The 5th KISR-Taiwan Institutes Joint Workshop on Advanced Technology Application. Taipei, Taiwan, 8th~11th June, 2015.
C. -I. Chang, C. -F. Lee, J. -M. Tsai, C. -C. Wu, L. -H. Chen and S. -C. Chen (2014) A selective and differential medium for isolation of pathogenic Lactococcus garvieae. The 10th Asia-Pacific Marine Biotechnology Conference. Taipei, Taiwan, 4th~8th May, 2014.
C. -I. Chang, C. -F. Lee, C. -C. Wu, L. -H Chen, and K. -J. Lin (2013) Development of a medium for isolation and presumptive identification of Lactococcus garvieae. 16th International Conference on Diseases of Fish and Shellfish. Tampere, Finland, 2nd~6th Sep. 2013.
Chin-I Chang, Chia-Fang Lee, Chih-Chien Chang, Chia-Che Wu and King-Jung Lin (2011) Development of a Medium for Isolation and Presumptive Identification of Vibrio alginolyticus, a Significant Pathogen of Grouper. International Symposium on Grouper Culture, Pingtung, Taiwan November 8th- 11th, 2011.
楊順德、張錦宜、周瑞良、劉富光 (2011) 開發日本鰻苗人工膏狀飼料取代絲蚯蚓馴餌。台灣水產學會學術論文發表會,高雄,台灣。12月3日,2011年。
C. -I. Chang (2010) Eel disease prevention and control. International Symposium on Eel Culture and Trade, Science City of Muñoz, Nueva Ecija, Philippines, 5th Feb. 2010.
T. C. Cheng, K. S. Yao, N. Yeh, C. -I. Chang, H. C. Hsu, F. Gonzalez and C. Y. Chang (2010) Bactericidal effect of blue LED light irradiated TiO2/Fe3O4 particles on marine fish pathogen. The 5th International Conference on Technological Advances of Thin Films & Surface Coatings, Harbin, China. July 11th- 14th, 2010.
T. -F. Chen, W. -C. Huang, H. -J. Chen, S. -H. Yang, C. -I. Chang, C. -W. Kuo (2009) Country paper for Republic of China. APO Seminar on Multicountry Observational Study Mission on Entrepreneurship and Agrotechnology / Agribusiness Incubation, Taichung, Taiwan, 22nd-26th Jun. 2009.
T.C. Cheng, C.Y. Chang, C.I. Chang, C.C. Hwang, H.H. Shu, D.Y. Wang and K.S. Yao (2008) Photocatalytic Bactericidal Effect of TiO2 Thin Film on Fish Pathogens. International Conference on Metallurgical Coatings and Thin Films, San Diego, CA, USA. April 28th- May 2nd, 2008.
T.C. Cheng, C.Y. Chang, C.I. Chang, C.J. Hwang, H.H. Shu, D.Y. Wang and K.S. Yao (2008) Visible light activated bactericidal effect of iron plasma ion implantation TiOthin film on fish pathogens. 4th Coatings Science International, Noordwijk, The Netherlands, June 23th - 27th, 2008.
李嘉偲、陳柏璇、黃美瑩、吳紹祺、張錦宜、潘崇良、洪良邦 (2008) 海洋細菌分離株所產粗酵素液對9種海藻多醣降解能力之初步探討。 台灣農業化學會第46次會員大會,台北,台灣,97年6月30日。
陳柏璇、李嘉偲、黃美瑩、洪良邦、張錦宜、林金榮、潘崇良 (2008) 經石蓴多醣萃取物誘導之海洋細菌所產粗酵素液對三種海藻多醣水解效率之探討。 台灣農業化學會第46次會員大會,台北,台灣,97年6月30日。
C. -I. Chang (2007) Innovative approaches for the effective agriculture technology commercialization for company and dissemination for small farmers. APO Seminar on Best Practices in Agricultural Technology Transfer, Colombo, Sri Lanka, 5th-9th Nov. 2007.
張錦宜 (2007) 生物技術在水產動物疾病檢測之應用研究. 2007農業生技研發成果暨產業趨勢研討會
C. -I. Chang, and C. J. Secombes (2006) Fish cathelicidins: novel antimicrobial peptides identified in rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar. Symposium on 2006 Scientific Cooperation in Agriculture between Council of Agriculture (Taiwan, R.O.C.) and Institut National de la Recherche Agronomique (France).

C. -I. Chang, O. Pleguezuelos, Y. -A. Zhang, J. Zou and C. J. Secombes (2004) Molecular cloning, gene organization and expression of a novel cathelicidin gene in rainbow trout Oncorhynchus Mykiss. 6th International Symposium on Fish Immunology.

C. –I. Chang, Y. –A. Zhang, O. Pleguezuelos and C. J. Secombes (2003) Cloning of a novel antimicrobial peptide gene belonging to the cathelicidin family in rainbow trout Oncorhynchus mykiss. 9th International congress of the International Society for Developmental and Comparative Immunology.